How does CBD Work?

CBD

CBD is not a psychoactive component of marijuana, which in recent years in Poland has aroused great interest of scientists and doctors. Still are ongoing studies confirming the effectiveness of this amazing remedy, but now it is known that CBD works! This is confirmed by hundreds of satisfied consumers.

How does CBD Work? Cooperation with receptors and ion channels

Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5-HT1A serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.

CBDA (Cannabidiolic acid), the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5-HT1A receptor. Preclinical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC, which also have anti-nausea properties.

CBD directly interacts with various ion channels to confer a therapeutic effect.TRPV1 is known to mediate pain perception, inflammation and body temperature.

CBD

Whereas cannabidiol directly activates the 5-HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.

GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors. GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.

GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis.

GPR55, when activated, also promotes cancer cell proliferation, according to a 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer.

CBD is a GPR55 antagonist, as University of Aberdeen scientist Ruth Ross disclosed at the 2010 conference of the International Cannabinoid Research Society in Lund, Sweden. By blocking GPR55 signaling, CBD may act to decrease both bone reabsorption and cancer cell proliferation.

CBD also exerts an anti-cancer effect by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell’s nucleus. Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines. PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.

How does CBD work and why reduces the psychoactive properties of THC?

Canadian scientists have identified CBD as a “negative allosteric modulator”. Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor that is concentrated in the brain and central nervous system. Cannabidiol does not bind to the CB1 receptor directly as THC. CBD interacts with CB1 and changes the shape of the receptor in a way that reduces the ability of CB1 to bind to THC. CBD reduces the THC psychoactive effect. The CBD-rich product with low THC content can transfer therapeutic benefits without the effect of euphoria and intoxication.

How CBD works and the oils with this cannabinoid can be found HERE.

Source:

https://www.projectcbd.org/science/cannabis-pharmacology/how-cbd-works

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